Models
Leveraging advanced techniques, such as in vivo studies, ex vivo assays, and vaccine profiling, we ensure clinically relevant outcomes, driving the transition from preclinical research to clinical trials seamlessly.
Custom Model Development:
Expertise (in-house or at partner’s site) generating genetically engineered models to mimic human diseases and provide reliable data for drug efficacy studies.
In Vivo and Ex Vivo Assays:
Advanced models to assess the therapeutic potential of compounds in clinically relevant conditions.
Drug Efficacy Testing:
Robust efficacy studies utilizing a variety of disease models to validate candidate drugs in oncology, immunology, neurology, and more.
Toxicology and Safety Evaluation:
Comprehensive testing to assess drug safety, pharmacokinetics, and toxicology in preclinical settings.
Immunotherapy and Vaccine Development:
Specialized models for evaluating immune responses and vaccine efficacy, ensuring reliable translation to clinical trials.
Histopathology and Imaging:
Detailed tissue analysis and state-of-the-art imaging to provide insights into treatment effects at the cellular level.
AthenaVax provides an extensive library of human and mouse cell lines for diverse research applications, including oncology, immunology, and genetic research.
Our collection includes:
- Human Cell Lines: Over 180 cell lines covering a wide range of cancers, including leukemia, liver, colorectal, lung, breast, ovarian, and pancreatic cancers.
- Luciferase-Tagged Cell Lines: Specialized cell lines tagged with luciferase for in vivo imaging, including leukemia (Nalm6-Luc), liver (Huh7-Luc), colorectal (HT-29-Luc), glioblastoma (U251-Luc), and more.
- Mouse Cell Lines: A selection of mouse cell lines, including genetically modified models for cancer research.
- Humanized Mouse Cell Lines: Cell lines engineered to express human genes, useful for studying human-specific drug interactions and immune responses.
Our cell lines are carefully selected to provide reliable, reproducible results for preclinical studies, enabling advanced drug discovery and therapeutic development.
AthenaVax offers a wide range of highly specialized models to accelerate the discovery and development of therapeutics
Our models include:
- Tumor Models: Preclinical models for pancreatic, breast, colon, lung, and other cancers, including genetically engineered models such as KRAS, EGFR, and p53 mutations, designed to mimic human tumor progression and treatment response.
- Spontaneous Tumor Models: Models such as the B6-Kras and B6-p53 series that spontaneously develop tumors, providing insight into cancer mechanisms and therapeutic interventions.
- Humanized Mouse Models: Models with humanized immune systems, proteins, and antibodies to enable the study of human-specific drug effects and antibody discovery.
- Customizable Knockout/Knockin Models: Genetically engineered mouse models designed for specific research needs, including gene knockouts, knockins, and transgenic lines for studying genetic disorders and therapeutic targets.